Journal article
Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
C Rosty, MD Walsh, RJ Walters, M Clendenning, SA Pearson, MA Jenkins, AK Win, JL Hopper, K Sweet, WL Frankel, M Aronson, S Gallinger, J Goldblatt, K Tucker, S Greening, MR Gattas, S Woodall, J Arnold, NI Walker, S Parry Show all
American Journal of Surgical Pathology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
Serrated polyposis (SP) is a clinically defined syndrome characterized by the occurrence of multiple serrated polyps in the large intestine. Individuals with SP and their relatives are at increased risk of colorectal carcinoma (CRC). We aimed to determine the pathologic and molecular profiles of CRCs in individuals fulfilling World Health Organization criteria for SP. A total of 45 CRCs were obtained from 38 individuals with SP (27 female and 11 male patients; median age at CRC diagnosis, 58.5 y) attending genetics clinics. Tumor samples were pathologically reviewed, screened for somatic BRAF and KRAS mutations, and analyzed immunohistochemically for mismatch repair protein (MMR) expression...
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
Supported by National Cancer Institute, National Institutes of Health under 1R01CA123010 (Genetics of Serrated Neoplasia) and RFA # CA-95-011 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735). During this work, J.P.Y. was a Cancer Council Queensland Senior Research Fellow. C. R. is a Jass Pathology Fellow. M.A.J. is an NHMRC Senior Research Fellow, and J.L.H. is an Australian fellow of the NHMRC. For the remaining authors none were declared.